I've been on Rapa for three years and my last dental checkup looked great. I will have to go back and get copies of my records to verify improvements.  

    Taken together, our data demonstrate that a short-term treatment with rapamycin in aged mice is sufficient to target three clinically defining features of periodontal disease: periodontal bone loss, periodontal inflammation, and pathogenic changes to the oral microbiome. To the best of our knowledge, this is the first report of rejuvenation in the aged oral cavity. It will be important in future studies to determine whether these effects are mediated through local inhibition of mTORC1 in the gingiva and periodontal bone or through systemic effects on immune function or other tissues. Likewise, it will be of interest to understand whether additional features of oral health that are known to decline with age, such as salivary function, are improved by rapamycin treatment. Finally, these results suggest the intriguing likelihood that additional geroscience interventions, such clearance of senescent cells, may phenocopy the effects of rapamycin in this context. Such interventions could pave the way for the first effective treatments to reverse periodontal disease and improve oral health in the elderly.